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By providing reducing equivalents for the glutathione system, NADPH supports regeneration of reduced glutathione (GSH) from its oxidized form (GSSG), which is essential for detoxification of hydrogen peroxide by glutathione peroxidases ( Among redox-dependent regulators, HIF-1α and NRF2 exemplify how mitochondrial signals are translated into nuclear transcriptional programs that affect the broader organelle network

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Neither study is sufficient to establish general efficacy, long-term safety or effectiveness for tendon repair