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In particular: NICE Technology Appraisal TA875 provides a positive recommendation for semaglutide (Wegovy) for chronic weight management in adults meeting specific criteria (BMI ≥35 kg/m² with at least one weight-related comorbidity, or BMI 30–34.9 kg/m² in certain circumstances), when used within a specialist weight management service
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This process is marked by chronic low-grade inflammation (“inflammaging”), diminished adaptive immunity, and a skewed CD4+/CD8+ T cell ratio, leaving older adults more vulnerable to infection, cancer, and poor vaccine responses [47]
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