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Indeed, Rho-associated protein kinase increases the sensitivity of vascular smooth muscle to calcium in hypertension (37) and coronary spasm (38)
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Further, mice treated with SRT1720, a potent, selective synthetic activator of SIRT1, were resistant to diet-induced obesity and insulin resistance due to enhanced oxidative metabolism in skeletal muscle, liver, and brown adipose tissue (see Supplementary Information)
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