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It enhances both synthesis and breakdown of extracellular matrix components, such as collagen, glycosaminoglycans (including dermatan and chondroitin sulfate), and decorin, and regulates metalloproteinases and their inhibitors (Pickart, Vasquez-Soltero, and Margolina 2015)

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If you are on weekly tirzepatide injections and crossing multiple time zones, plan your injection day so it falls at a consistent interval