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More recent genetic and structural approaches have built on early work done in the 1950s (Reference Melville, Horner and Otken11–Reference Melville, Genghof and Inamine13) and demonstrated that ergothioneine biosynthesis has independently emerged at least three times in the molecular evolution of mycobacteria, anaerobic archaebacteria and cynaobacteria (Reference Stampfli, Blankenfeldt and Seebeck10)
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