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Furthermore, HT demonstrated its ability to provide protection against oxidative stress, inflammation, hyperglycemia, and hyperlipidemia in animal models by decreasing levels of inflammatory cytokines, serum CRP, and TBARS in the liver, kidney, heart, and pancreas while increasing mitochondrial biogenesis, oxygen consumption capacity, ATP production, and cell viability

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Spermidine may regulate the Akt/FHC/ACSL4 pathway to inhibit ferroptosis in porcine ovarian granulosa cells, with possible implications for ovarian reserve and fertility (Niu et al., 2023)