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A peptide that modulates VEGFR2 in a cell culture dish, or heals a rat tendon at 10 mcg/kg IP injection, has not been shown to survive oral delivery in a human at 500 mcg and reach musculoskeletal tissue at any meaningful concentration

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Viral-mediated delivery of HSP72 or HSP60 has demonstrated efficacy in preclinical models, improving metabolic parameters and preventing disease progression