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NOX4 deletion accelerated hepatocyte proliferation after partial hepatectomy (Herranz-Itúrbide et al., 2021)—which is an essential component of the response—but also accelerated proliferation and migration in hepatocellular carcinoma (Crosas-Molist et al., 2014), suggesting that inhibiting NOX4 could exacerbate the progression of liver disease associated with obesity
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