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Endogenous glucocorticoids regulate the circadian expression of a number of inflammatory cytokines through binding to the intracellular GR, which suppresses the expression of inflammatory mediators by interacting with GREs and by directly regulating transcription factors such as NF-κB, Activator protein-1 (AP-1) as transrepression 59 (Fig

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[DOI] [PubMed] [Google Scholar] 49.Brady RO, Jr, McCarthy JM, Prescot AP, Jensen JE, Cooper AJ, Cohen BM, et al