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Amino acid related metabolic pathways were disrupted in both serum metabolic group and liver metabolic group in this experiment

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The two SNPs are associated with altered P-glycoprotein function, in which the Ser893 variant transporter resulted in a 47% lower intracellular digoxin concentration ( p Ser) variant significantly impaired uptake kinetics of endogenous compounds and drugs (Zolk et al., 2009