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A peptide is a chain of amino acids held together by peptide bonds, and those bonds are precisely what digestive enzymes (pepsin, trypsin) are built to cut, with the acidic stomach environment finishing the job — so an oral peptide is largely destroyed before it can be absorbed, which is why injection is the default

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[DOI] [PubMed] [Google Scholar] 77.Bishayee A., Barnes K.F., Bhatia D., Darvesh A.S., Carroll R.T