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However, given the immense quantity of spines in the mouse cortex (~10,000 per neuron), the number of learning-induced and subsequently maintained new spines could be around 2 × 10 6 , large enough to have a significant and lifelong impact on neural network functions and animal’s behavior (Arenz et al., 2008

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The first 72-week non-diabetic obesity dose is 5 mg weekly.¹ The lowest measured human trial dose is 1 mg weekly in type 2 diabetes.²¹ Is 2.5 mg tirzepatide therapeutic