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Tuftsin-Receptor-Mediated Tolerogenic DC Biology Selank’s tuftsin receptor activity in dendritic cells promotes tolerogenic DC differentiation — reduced IL-12p70, elevated IL-10 secretion — that may expand Treg peripherally in a Tα1-complementary but mechanistically distinct manner

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Often, the mechanisms of action of these peptides remain unclear, while long-term downstream effects on the body are poorly understood