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The role of OS in the pathogenesis and/or complications of numerous diseases is well-established [[9], [10], [11]], including cancer, diabetes, neurological disorders, and cardiovascular issues

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[0158] Thus in one aspect, there is provided: a method of inducing conditions characterised by one or more deficient genes (or genotyoes) or gene knockdowns in a post-mitotic cell, comprising: transducing a first population of cells with a non-naturally occurring or engineered composition comprising a vector system comprising one or more vectors comprising I