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Improving the pharmacokinetics and biodistribution of drugs is one of the primary advantages of surfactant-based DDSs, and they are capable of ensuring that greater amounts of drug are delivered to the tumor site by restricting premature drug release and reducing the agglomeration of hydrophobic drugs [50]

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Notably caffeine and nicotine are being monitored for in-competition use and codeine, fentanyl and tramadol for out-of-competition use