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Researchers may track changes in molecular markers, such as pathway readouts or gene-expression signals, to better understand how short peptides can probe age-related cellular processes in experimental models
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In particular, the fungal PP motif (Mompeán et al., 2018), recently complemented by the structure of RIPK3 solved by cryo-EM in combination with SSNMR (Wu et al., 2021), and it remains to be solved if the sequence similarity between fungal and mammals necroptotic amyloid motifs translate into structure similarity
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