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It suppresses TNF-α and IL-1β secretion from activated macrophages and stromal cells, downregulates matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF), thereby reducing extracellular matrix degradation, cell invasion, and pathological angiogenesis, and significantly decreases adhesion formation between ectopic lesions and adjacent peritoneal surfaces
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The results of this study show that the tetrahydroisoquinoline derivative 82 was equal to Pioglitazone in terms of insulin-sensitizing properties, with minor adverse effects
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