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Interestingly, the initial product of the elimination reaction (aminoacrylate or aminoacrylate in Schiff base linkage to PLP cofactor) was also found to covalently add to a susceptible protein residue

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1C Effects of the NNMT inhibitor 5-amino-1MQ on intracellular levels of SAM, SAH, SAM:SAH ratio in differentiated adipocytes (3T3 cells) treated with the inhibitor (30 ⁇ M) for 24 h