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Deficiency is commonly caused by aging, poor diet, alcohol use, stomach disorders, pernicious anemia, or long-term medication that blocks absorption

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And when enough folks have curtailed the risks posed by the drug supply, epi nerds would call it the “depletion of susceptibles.” Let’s get messy and imagine that we can aggregate every person who (potentially) uses opioids based on their risk (i.e., type, amount, and route of substances used) and tolerance (i.e., physiological and practical adaptation to substances)