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Figure 1 3.1 Oxidative stress Oxidative stress generated by hyperglycemia-induced mitochondrial superoxide excess is one of the pathological mechanisms of DR ( Protein kinase C (PKC) is a serine/threonine kinase involved in signal transduction that responds to the stimulation of specific hormones, neurons, and growth factors ( 3.2 Inflammation Chronic Inflammation is associated with developing diabetes and its complications ( In addition, increased diacylglycerol (DAG) production via the glycolytic pathway activates PKC under hyperglycemia ( 3.3 Vascular endothelial growth factor and neovascularization Neovascularization is one of the critical features of PDR

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doi: 10.1111/j.1365-2125.2010.03722.x