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CD38, a multifunctional ectoenzyme highly expressed on malignant plasma cells, contributes to this niche by degrading nicotinamide adenine dinucleotide (NAD + ) into ADPR, which fuels adenosine (ADO) production through CD38/CD203a/CD73 enzymatic pathway
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Glutathione peroxidases (GPXs) are an enzyme family with peroxidase activity that protects organisms from oxidative damage by reducing lipid hydroperoxides and free hydrogen peroxide 5
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