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Under physiological conditions, the protein level of Nrf2 is low because it binds to its negative regulatory factor kelch-like epichlorohydrin-associated protein 1 (Keap1), which forms the E3 ubiquitin ligase complex and facilitates ubiquitination and subsequent degradation of Nrf2 by the 26S proteasome [51]

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Polycytosine RNA-binding protein 1 regulates osteoblast function via a ferroptosis pathway in type 2 diabetic osteoporosis