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However, a recent study suggests that heme-mediated activation of the Nrf2/HO-1 pathway inhibits the calcification of VICs in vitro , a contradiction to an earlier report ( 5 CARDIAC IRON OVERLOAD Thalassemia, sickle cell anemia, primary hemochromatosis, and other diseases that require long-term repeated blood transfusions or iron supplements can lead to cardiac iron overload (Murphy and Oudit, 2010

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While NRF1 and NRF2 are differentially regulated by KEAP1 60 , both have overlapping targets and roles in preventing liver-related diseases 61