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This is because nature has employed a “mix-and-match” approach in the evolution of metal-sensing operons or regulons in a specific organism, likely aided by horizontal gene transfer 247 and subsequent convergent evolution

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Some GWAS loci may be ethnicity-specific: lipid rafts – macromolecular complexes that regulate cell mechanotransduction – have been linked to POAG in European cohorts (23) via mutations in CAV1 and CAV2