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TNF-α, IL-1 β and IL-6 are associated with activation of bone-resorbing processes, and IL-8 is reported to polymorphonuclear leukocyte activity.[5,34] More recently, Dias et al .,[99] first time revealed that significant redox disturbances exist in neutrophils of patients with periodontitis, which are associated with deregulation of anti-inflammatory transcription factor Nrf2 pathway resulting in neutrophil hyperactivity/hyper-reactivity