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This happens in conditions like pregnancy, several diseases, and with use of oral contraceptives (which is sometimes prescribed for menstrual migraine)

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For example, the increased level of miR-146a can suppress IFN-γ-dependent Th1 responses and reduce Th1-mediated lesions by Tregs inhibition of signal transducer and activator of transcription 1 (Lu et al., 2010), and diminish adhesion of T cells to endothelial cells (Wu et al., 2015)