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For subcutaneous injections, pinch the skin and poke the needle in at a 90-degree angle, almost like you're throwing a dart, so it barely goes beneath the surface
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Most common adverse events at all doses: Nausea (33–55%, dose-related) Vomiting (13–35%) Decreased appetite (15–28%) Constipation or diarrhea (10–20%) Injection-site reaction (5–10%) Dose-related dysesthesia signal: The TRIUMPH-4 trial identified a dose-related dysesthesia (nerve-tingling, paresthesia) signal: This is the most-flagged trial-level safety signal for retatrutide and the reason community doses cluster at 2-4 mg/week — well below where the dysesthesia signal becomes prominent