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In mice from the negative control group (microphotograph 2), a loss of neuronal tissue integrity was observed, marked by the presence of hyperchromatic cells (Figures 12A,B), degradation of the polymorphic, granular, and molecular layers, and necrosis (Figure 12C)

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Cabozantinib for previously treated radioiodine-refractory differentiated thyroid cancer: updated results from the phase 3 COSMIC-311 trial