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List of abbreviations AA Ascorbic Acid ACTH Adrenocorticotrophic Hormone CGD Chronic Granulomatous Disease DHA Dehydroascorbic Acid EAR Estimated Average Requirements FIH Factor Inhibiting HIF GLUT Glucose Transporter GRD Glutathione Reductase GSH Glutathione GSSG Glutathione Disulfide HIF Hypoxia Inducible Factor HPLC High Performance Liquid Chromatography NADPH Nicotinamide Adenine Dinucleotide Phosphate RDA Recommended Dietary Allowance RNOS Reactive Nitrogen Oxide Species ROS Reactive Oxygen Species SNP Single Nucleotide Polymorphism SVCT Sodium dependent Vitamin C Transporter Footnotes Author Contributions SJ Padayatty composed the initial draft of the manuscript and figures

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