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Expression of Genetically Engineered Membrane Receptors G protein-coupled receptors (GPCRs) regulate a wide variety of cellular functions by converting extracellular signals (light, toxins, nutrients, ions, and hormones) into intracellular signals via the production of second messengers, i.e., cAMP, phosphatidylinositol 4,5-bisphosphate, and Ca 2+
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