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Patients who underwent randomization were treated with at least one dose of study medication, and had available post-baseline data on exacerbation were included in the FAS for exacerbation, and those who had available spirometry data at 12 months or 24 months were included in the FAS for lung function

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Its absence leads to reduced expression of glucose transporters GLUT1 and GLUT4 in the brain, and GLUT3 and GLUT4 in peripheral tissues