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Tirzepatide Maintenance Dose After Weight Loss The clearest maintenance band is 5–10 mg weekly, based on the obesity dose-response curve and real-world prescribing.¹ ¹⁸ A 2.5 mg track has short direct data and real-world support for stable maintainers, but no long-duration maintenance trial.¹⁸ Continuing tirzepatide holds weight far better than stopping