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Additionally, the APAP-induced elevations of circulating alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were attenuated in Bcl3 hep-/- mice at 6 and 24 hours, as well lactate dehydrogenase (LDH) levels (Figure 2 K–M )

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That two-size lineup is the practical draw: you can start with the standard vial and step up to 30mL only if your bench workload genuinely calls for it