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3.5 Stability Under Synthesis Conditions The diazirine ring of Fmoc-L-Photo-Methionine is stable under all standard Fmoc-SPPS conditions: piperidine-mediated Fmoc deprotection (20% piperidine/DMF), amino acid coupling with HATU/DIPEA, HBTU/DIPEA, or PyBOP/NMM, side-chain deprotection and resin cleavage with TFA-based cocktails (e.g., TFA/TIS/H2O 95:2.5:2.5, 2–4 h at RT), and reverse-phase HPLC purification in aqueous acetonitrile/TFA or formic acid gradients

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Pack:Pack of 1 (60 Tablets)

Vaccines (Basel) (2020) 8:20200602

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