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In addition, serum PLP level has been shown to be a risk factor for chronic diseases and even some cancers, such as colon cancer.[11,12,13] The causes of vitamin B12 deficiency in patients with UC include anemia, decreased absorption of cyanocobalamin due to the inflammation of the colon, decreased consumption of food sources of vitamin B12, liver dysfunction, and ileum resections.[3,5] In addition, in a study, the impact of cyanocobalamin has been shown in control of chronic and acute pain as well as its anti-inflammatory effect.[14] Considering micronutrient deficiencies in UC patients and also the role of vitamins in reducing inflammation and modulating immune system responses, this study was conducted to investigate the ameliorative effect of selected B vitamins (B1, B2, B6, and B) at normal (daily recommended) and high (mega) doses in an animal experimental model of colitis
