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After removing duplicates and completing the screening processes, we included 36 articles in this systematic review [1,2,4–7,15–20,22,23,25,33,35,36,39,40,41,44–53,60–62,66,67], with 21 reporting on the mechanism of action [1,2,5,6,16–20,23,35,40,41,47,50,52,53,60–62,66], 15 reporting musculoskeletal outcomes [2,4–6,19,22,22,25,33,36,39,46,48,49], 3 analyzing metabolism [7,15,51], and 4 assessing safety profile and adverse effects associated with BPC-157 [15,45,45,67] (Fig