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The government arrested all monks who refused to register and closed down any monasteries that fostered anti-government dissent.[11] Within a year, the government had arrested 900 monks on charges of engaging in anti-government activity.[12] In 1971, in the midst of a protracted economic downturn, Ne Win retired from the military and oversaw the transition from the military-led Revolutionary Council to a nominally civilian-led government run by the Burma Socialist Programme Party (BSPP), of which he was the head.[13] The BSPP began drafting a new constitution at the end of 1972.[14] While the government claimed to engage in public consultation, security forces arrested leaders of ethnic minorities, particularly ethnic Chin, who called for the adoption of federalism and a multiparty system.[15] After a strictly controlled public vote, the new Constitution went into effect at the beginning of 1974
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The water-soluble nature of B12 means several things for patients : the vitamin requires regular dietary intake to maintain optimal levels, it can be lost during food preparation (particularly with prolonged cooking or boiling), and therapeutic doses are generally considered safe as excess is eliminated through the kidneys, though the body's substantial hepatic storage also plays a role in B12 metabolism