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Water and salts can easily penetrate brain tissue if in case the BBB is damaged due to mechanical injury or illness (13) leading to a rise in intracranial pressure and edema (63)
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Specifically, the risk of manic episodes is notably higher in patients treated for severe psoriasis (HR = 12.6), and psychotic disorders have been observed with a higher frequency in ulcerative colitis patients treated with IFX (HR = 5.43) (Thillard et al., 2020)
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