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Most manufacturers recommend refrigeration at 2-8°C even for unopened vials, though some formulations remain stable at room temperature for short periods

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In this review, we introduce advances in immune microenvironment-driven immunotherapies for HCC, describe varieties of aberrant lipid metabolism in the liver that guide the application of statin as a cholesterol-lowering agent in HCC treatment, and discuss the potential use of stain in future immune therapy strategies for combinational treatment, based on observations mostly from long-term population studies and clinical trials