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No sedative effects were observed on any measure, no cognitive impairment was detected on neuropsychological testing, and no withdrawal symptoms occurred after discontinuation

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As Kannt & Pfenninger highlight in Frontiers in Physiology , maintaining NAD⁺ levels is a cornerstone of metabolic health, supporting mitochondrial function and improving resistance to metabolic stress (Kannt & Pfenninger, Frontiers in Physiology )