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Other excellent reviews address the role of compartmentalized GSH pools (mitochondria and endoplasmic reticulum) (6, 166), specific GSH-dependent antioxidant systems (119, 159), and GSH-based protein modifications in cell death (2, 50)
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While Paneth cells show an enhanced glycolytic phenotype and secrete lactate, the metabolism of the Lgr5 + stem cells is based on increased OXPHOS which is supported by the secreted lactate of the Paneth cells
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