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Many studies indicate that quercetin can inhibit the generation of osteoclast-like cells, bone resorption depression, and F-actin ring formation in RAW264.7 cells, bone-marrow macrophages, and human peripheral-blood mononuclear cells pre-treated with RANKL or macrophage colony-stimulating factor ( RA affects extra-articular tissues and organs, including blood vessels, the nervous and gastrointestinal systems, heart, lung, and kidneys