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TPO reduces the pairs of iodinated tyrosine in thyroglobulin in order to form thyroxine and triiodothyronine using hydrogen peroxide, heme beta and Ca2+ as cofactors ( Glutathione peroxidase 3 (GPX3) catalyzes the reduction of H2O2 and is highly abundant in the thyroid gland ( In thyroid dysfunctions, oxidative stress accompanied by thyroid epithelial cell inflammation is frequently observed
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