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It also demonstrated the counteraction of the adverse effects of either NOS blockade (L-NAME) or NOS substrate L-arginine application (i.e., it opposed hypertension and pro-thrombotic effects (L-NAME) [26,55], as well as hypotension and anti-thrombotic (L-arginine) effects [26,55])

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1000 µg IM daily or every other day for 1–2 weeks, then 1000 µg once weekly for 4–8 weeks