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Inflammation OT is well known to modulate the immune system, generally reducing inflammatory cytokines/factors such as IL-6, IL-1β, and TNF-α,⁴ and raising anti-inflammatory cytokines/factors, inclusive of VEGF, IL-4, IL-6, IL-1b, IL-10, ICAM-1, TGF-β, endorphins, adrenocorticotropic hormone (ACTH), and cortisol levels.⁵⁶⁷ This is a major beneficial effect since untreated inflammation is universally accepted as the main cause of vascular and organ injury, damage in infection, and aging