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Locally, lidocaine-medicated patches, through their action of blockade of voltage-gated sodium channels and stabilization of the neuronal membranes as well as inhibition of ectopic discharge, are applicable to treat peripheral pain, e.g., around a surgical scar around the elbow [65]
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The paracrine mechanism—driven by released factors and exosomes—regulates inflammatory processes, enhances endogenous cell proliferation, prevents programmed cell death, and aids extracellular matrix reconstruction, which is now understood as the predominant therapeutic mechanism in living systems [19], [28]
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