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Modulating G-protein-coupled receptors: from traditional pharmacology to allosterics - ScienceDirect
Insomnia symptoms can be associated with sleep apnea, restless legs syndrome, circadian-rhythm disorders, anxiety, depression, pain, reflux, menopause symptoms, thyroid conditions, alcohol, stimulants, medications and inconsistent sleep schedules
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For example, NO inhibits metalloproteins involved in cellular respiration, such as the citric acid cycle enzyme aconitase and the electron transport chain protein cytochrome oxidase