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More recently, the development of selective monoamine oxidase-B (MAO-B) inhibitors, selegiline, and rasagiline, which slow the degradation of dopamine formed from L-DOPA and prolong its duration of effect, as well as the more recent development of catechol-O-methyl-transferase (COMT) inhibitors, entacapone, and tolcapone, which stop either the peripheral or central metabolism of L-DOPA to 3-O-methyldo [22, 74]
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