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While it was shown that GDF8 and GDF11 signal through similar receptors, a direct rigorous comparison of the ligands had not been performed until we published a study demonstrating that GDF8 and GDF11 have significant differences in their signaling properties in multiple cell lines, showing that GDF11 is much more potent than GDF8

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5-Amino-1MQ alters histone methylation and metabolic programs in cancer and aging models, representing a promising target for longevity and oncology research [9]

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