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All animal experiments described were approved by the IACUC at the University of Texas at Southwestern (Animal Protocol Number [APN] 2021-103130, 2020-102949)

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Persistent senescent cells have been associated with aging or age-related diseases via secretion of proinflammatory cytokines that alter the tissue microenvironment or modify the function of normal cells (Baker et al., 2010) demonstrated that elimination of senescent cells in prematurely aged mice can prevent many age-related diseases

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